Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin
Identifieur interne : 001120 ( Main/Exploration ); précédent : 001119; suivant : 001121Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin
Auteurs : Jean K. Millet [États-Unis] ; Karin Séron [France] ; Rachael N. Labitt [États-Unis] ; Adeline Danneels [France] ; Kenneth E. Palmer [États-Unis] ; Gary R. Whittaker [États-Unis] ; Jean Dubuisson [France] ; Sandrine Belouzard [France]Source :
- Antiviral Research [ 0166-3542 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (pharmacologie), Cellules cultivées, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Humains, Infections à coronavirus (virologie), Lectines végétales (pharmacologie), Lignée cellulaire, Produits biologiques (pharmacologie), Pénétration virale (), Relation dose-effet des médicaments, Réplication virale (), Survie cellulaire ().
- MESH :
- pharmacologie : Antiviraux, Lectines végétales, Produits biologiques.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Infections à coronavirus.
- Animaux, Cellules cultivées, Coronavirus du syndrome respiratoire du Moyen-Orient, Humains, Lignée cellulaire, Pénétration virale, Relation dose-effet des médicaments, Réplication virale, Survie cellulaire.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Biological Products (pharmacology), Cell Line, Cell Survival (drug effects), Cells, Cultured, Coronavirus Infections (virology), Dose-Response Relationship, Drug, Humans, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (physiology), Plant Lectins (pharmacology), Virus Internalization (drug effects), Virus Replication (drug effects).
- MESH :
- chemical , pharmacology : Antiviral Agents, Biological Products, Plant Lectins.
- drug effects : Cell Survival, Middle East Respiratory Syndrome Coronavirus, Virus Internalization, Virus Replication.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections.
- Animals, Cell Line, Cells, Cultured, Dose-Response Relationship, Drug, Humans.
- mix :
Abstract
Highly pathogenic human coronaviruses associated with a severe respiratory syndrome, including Middle East respiratory syndrome coronavirus (MERS-CoV), have recently emerged. The MERS-CoV epidemic started in 2012 and is still ongoing, with a mortality rate of approximately 35%. No vaccine is available against MERS-CoV and therapeutic options for MERS-CoV infections are limited to palliative and supportive care. A search for specific antiviral treatments is urgently needed. Coronaviruses are enveloped viruses, with the spike proteins present on their surface responsible for virus entry into the target cell. Lectins are attractive anti-coronavirus candidates because of the highly glycosylated nature of the spike protein. We tested the antiviral effect of griffithsin (GRFT), a lectin isolated from the red marine alga
Url:
DOI: 10.1016/j.antiviral.2016.07.011
PubMed: 27424494
PubMed Central: 7113895
Affiliations:
- France, États-Unis
- Hauts-de-France, Kentucky, Nord-Pas-de-Calais, État de New York
- Ithaca (New York), Lille
- Université Cornell
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000A60
- to stream Pmc, to step Curation: 000A60
- to stream Pmc, to step Checkpoint: 000A73
- to stream PubMed, to step Corpus: 001045
- to stream PubMed, to step Curation: 001045
- to stream PubMed, to step Checkpoint: 000F86
- to stream Ncbi, to step Merge: 001702
- to stream Ncbi, to step Curation: 001702
- to stream Ncbi, to step Checkpoint: 001702
- to stream Hal, to step Corpus: 000015
- to stream Hal, to step Curation: 000015
- to stream Hal, to step Checkpoint: 000013
- to stream Main, to step Merge: 001124
- to stream Main, to step Curation: 001120
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin</title><author><name sortKey="Millet, Jean K" sort="Millet, Jean K" uniqKey="Millet J" first="Jean K." last="Millet">Jean K. Millet</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">Ithaca (New York)</settlement></placeName><orgName type="university">Université Cornell</orgName></affiliation></author><author><name sortKey="Seron, Karin" sort="Seron, Karin" uniqKey="Seron K" first="Karin" last="Séron">Karin Séron</name><affiliation wicri:level="3"><nlm:aff id="aff2">Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Labitt, Rachael N" sort="Labitt, Rachael N" uniqKey="Labitt R" first="Rachael N." last="Labitt">Rachael N. Labitt</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">Ithaca (New York)</settlement></placeName><orgName type="university">Université Cornell</orgName></affiliation></author><author><name sortKey="Danneels, Adeline" sort="Danneels, Adeline" uniqKey="Danneels A" first="Adeline" last="Danneels">Adeline Danneels</name><affiliation wicri:level="3"><nlm:aff id="aff2">Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Palmer, Kenneth E" sort="Palmer, Kenneth E" uniqKey="Palmer K" first="Kenneth E." last="Palmer">Kenneth E. Palmer</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Whittaker, Gary R" sort="Whittaker, Gary R" uniqKey="Whittaker G" first="Gary R." last="Whittaker">Gary R. Whittaker</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">Ithaca (New York)</settlement></placeName><orgName type="university">Université Cornell</orgName></affiliation></author><author><name sortKey="Dubuisson, Jean" sort="Dubuisson, Jean" uniqKey="Dubuisson J" first="Jean" last="Dubuisson">Jean Dubuisson</name><affiliation wicri:level="3"><nlm:aff id="aff2">Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Belouzard, Sandrine" sort="Belouzard, Sandrine" uniqKey="Belouzard S" first="Sandrine" last="Belouzard">Sandrine Belouzard</name><affiliation wicri:level="3"><nlm:aff id="aff2">Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27424494</idno><idno type="pmc">7113895</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113895</idno><idno type="RBID">PMC:7113895</idno><idno type="doi">10.1016/j.antiviral.2016.07.011</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000A60</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A60</idno><idno type="wicri:Area/Pmc/Curation">000A60</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A60</idno><idno type="wicri:Area/Pmc/Checkpoint">000A73</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A73</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:27424494</idno><idno type="wicri:Area/PubMed/Corpus">001045</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001045</idno><idno type="wicri:Area/PubMed/Curation">001045</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001045</idno><idno type="wicri:Area/PubMed/Checkpoint">000F86</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F86</idno><idno type="wicri:Area/Ncbi/Merge">001702</idno><idno type="wicri:Area/Ncbi/Curation">001702</idno><idno type="wicri:Area/Ncbi/Checkpoint">001702</idno><idno type="wicri:doubleKey">0166-3542:2016:Millet J:middle:east:respiratory</idno><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-02104470</idno><idno type="url">https://hal.archives-ouvertes.fr/hal-02104470</idno><idno type="wicri:Area/Hal/Corpus">000015</idno><idno type="wicri:Area/Hal/Curation">000015</idno><idno type="wicri:Area/Hal/Checkpoint">000013</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000013</idno><idno type="wicri:doubleKey">0166-3542:2016:Millet J:middle:east:respiratory</idno><idno type="wicri:Area/Main/Merge">001124</idno><idno type="wicri:Area/Main/Curation">001120</idno><idno type="wicri:Area/Main/Exploration">001120</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin</title><author><name sortKey="Millet, Jean K" sort="Millet, Jean K" uniqKey="Millet J" first="Jean K." last="Millet">Jean K. Millet</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">Ithaca (New York)</settlement></placeName><orgName type="university">Université Cornell</orgName></affiliation></author><author><name sortKey="Seron, Karin" sort="Seron, Karin" uniqKey="Seron K" first="Karin" last="Séron">Karin Séron</name><affiliation wicri:level="3"><nlm:aff id="aff2">Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Labitt, Rachael N" sort="Labitt, Rachael N" uniqKey="Labitt R" first="Rachael N." last="Labitt">Rachael N. Labitt</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">Ithaca (New York)</settlement></placeName><orgName type="university">Université Cornell</orgName></affiliation></author><author><name sortKey="Danneels, Adeline" sort="Danneels, Adeline" uniqKey="Danneels A" first="Adeline" last="Danneels">Adeline Danneels</name><affiliation wicri:level="3"><nlm:aff id="aff2">Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Palmer, Kenneth E" sort="Palmer, Kenneth E" uniqKey="Palmer K" first="Kenneth E." last="Palmer">Kenneth E. Palmer</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Whittaker, Gary R" sort="Whittaker, Gary R" uniqKey="Whittaker G" first="Gary R." last="Whittaker">Gary R. Whittaker</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">Ithaca (New York)</settlement></placeName><orgName type="university">Université Cornell</orgName></affiliation></author><author><name sortKey="Dubuisson, Jean" sort="Dubuisson, Jean" uniqKey="Dubuisson J" first="Jean" last="Dubuisson">Jean Dubuisson</name><affiliation wicri:level="3"><nlm:aff id="aff2">Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Belouzard, Sandrine" sort="Belouzard, Sandrine" uniqKey="Belouzard S" first="Sandrine" last="Belouzard">Sandrine Belouzard</name><affiliation wicri:level="3"><nlm:aff id="aff2">Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d'Infection et d'Immunité de Lille, F-59000, Lille</wicri:regionArea><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></analytic><series><title level="j">Antiviral Research</title><idno type="ISSN">0166-3542</idno><idno type="eISSN">1872-9096</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Biological Products (pharmacology)</term><term>Cell Line</term><term>Cell Survival (drug effects)</term><term>Cells, Cultured</term><term>Coronavirus Infections (virology)</term><term>Dose-Response Relationship, Drug</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>Plant Lectins (pharmacology)</term><term>Virus Internalization (drug effects)</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Cellules cultivées</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Humains</term><term>Infections à coronavirus (virologie)</term><term>Lectines végétales (pharmacologie)</term><term>Lignée cellulaire</term><term>Produits biologiques (pharmacologie)</term><term>Pénétration virale ()</term><term>Relation dose-effet des médicaments</term><term>Réplication virale ()</term><term>Survie cellulaire ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Biological Products</term><term>Plant Lectins</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Virus Internalization</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Lectines végétales</term><term>Produits biologiques</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Cells, Cultured</term><term>Dose-Response Relationship, Drug</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Humains</term><term>Lignée cellulaire</term><term>Pénétration virale</term><term>Relation dose-effet des médicaments</term><term>Réplication virale</term><term>Survie cellulaire</term></keywords><keywords scheme="mix" xml:lang="en"><term>Antiviral</term><term>Lectin</term><term>MERS-CoV</term><term>Virus entry</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Highly pathogenic human coronaviruses associated with a severe respiratory syndrome, including Middle East respiratory syndrome coronavirus (MERS-CoV), have recently emerged. The MERS-CoV epidemic started in 2012 and is still ongoing, with a mortality rate of approximately 35%. No vaccine is available against MERS-CoV and therapeutic options for MERS-CoV infections are limited to palliative and supportive care. A search for specific antiviral treatments is urgently needed. Coronaviruses are enveloped viruses, with the spike proteins present on their surface responsible for virus entry into the target cell. Lectins are attractive anti-coronavirus candidates because of the highly glycosylated nature of the spike protein. We tested the antiviral effect of griffithsin (GRFT), a lectin isolated from the red marine alga <italic>Griffithsia</italic> sp. against MERS-CoV infection. Our results demonstrate that while displaying no significant cytotoxicity, griffithsin is a potent inhibitor of MERS-CoV infection. Griffithsin also inhibits entry into host cells of particles pseudotyped with the MERS-CoV spike protein, suggesting that griffithsin inhibits spike protein function during entry. Spike proteins have a dual function during entry, they mediate binding to the host cell surface and also the fusion of the viral envelope with host cell membrane. Time course experiments show that griffithsin inhibits MERS-CoV infection at the binding step. In conclusion, we identify griffithsin as a potent inhibitor of MERS-CoV infection at the entry step.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alhogbani, T" uniqKey="Alhogbani T">T. Alhogbani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belouzard, S" uniqKey="Belouzard S">S. Belouzard</name></author><author><name sortKey="Chu, V C" uniqKey="Chu V">V.C. Chu</name></author><author><name sortKey="Whittaker, G R" uniqKey="Whittaker G">G.R. Whittaker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belouzard, S" uniqKey="Belouzard S">S. Belouzard</name></author><author><name sortKey="Millet, J K" uniqKey="Millet J">J.K. Millet</name></author><author><name sortKey="Licitra, B N" uniqKey="Licitra B">B.N. Licitra</name></author><author><name sortKey="Whittaker, G R" uniqKey="Whittaker G">G.R. Whittaker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Rajashankar, K R" uniqKey="Rajashankar K">K.R. Rajashankar</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Agnihothram, S S" uniqKey="Agnihothram S">S.S. Agnihothram</name></author><author><name sortKey="Liu, C" uniqKey="Liu C">C. Liu</name></author><author><name sortKey="Lin, Y L" uniqKey="Lin Y">Y.-L. Lin</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author><author><name sortKey="Li, F" uniqKey="Li F">F. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, G" uniqKey="Lu G">G. Lu</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y. Hu</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q. Wang</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J. Qi</name></author><author><name sortKey="Gao, F" uniqKey="Gao F">F. Gao</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name></author><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y. Yuan</name></author><author><name sortKey="Bao, J" uniqKey="Bao J">J. Bao</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B. Zhang</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y. Shi</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J. Yan</name></author><author><name sortKey="Gao, G F" uniqKey="Gao G">G.F. Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meuleman, P" uniqKey="Meuleman P">P. Meuleman</name></author><author><name sortKey="Albecka, A" uniqKey="Albecka A">A. Albecka</name></author><author><name sortKey="Belouzard, S" uniqKey="Belouzard S">S. Belouzard</name></author><author><name sortKey="Vercauteren, K" uniqKey="Vercauteren K">K. Vercauteren</name></author><author><name sortKey="Verhoye, L" uniqKey="Verhoye L">L. Verhoye</name></author><author><name sortKey="Wychowski, C" uniqKey="Wychowski C">C. Wychowski</name></author><author><name sortKey="Leroux Roels, G" uniqKey="Leroux Roels G">G. Leroux-Roels</name></author><author><name sortKey="Palmer, K E" uniqKey="Palmer K">K.E. Palmer</name></author><author><name sortKey="Dubuisson, J" uniqKey="Dubuisson J">J. Dubuisson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Millet, J K" uniqKey="Millet J">J.K. Millet</name></author><author><name sortKey="Whittaker, G R" uniqKey="Whittaker G">G.R. Whittaker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mori, T" uniqKey="Mori T">T. Mori</name></author><author><name sortKey="O Keefe, B R" uniqKey="O Keefe B">B.R. O'Keefe</name></author><author><name sortKey="Sowder, R C" uniqKey="Sowder R">R.C. Sowder</name></author><author><name sortKey="Bringans, S" uniqKey="Bringans S">S. Bringans</name></author><author><name sortKey="Gardella, R" uniqKey="Gardella R">R. Gardella</name></author><author><name sortKey="Berg, S" uniqKey="Berg S">S. Berg</name></author><author><name sortKey="Cochran, P" uniqKey="Cochran P">P. Cochran</name></author><author><name sortKey="Turpin, J A" uniqKey="Turpin J">J.A. Turpin</name></author><author><name sortKey="Buckheit, R W" uniqKey="Buckheit R">R.W. Buckheit</name></author><author><name sortKey="Mcmahon, J B" uniqKey="Mcmahon J">J.B. McMahon</name></author><author><name sortKey="Boyd, M R" uniqKey="Boyd M">M.R. Boyd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moulaei, T" uniqKey="Moulaei T">T. Moulaei</name></author><author><name sortKey="Shenoy, S R" uniqKey="Shenoy S">S.R. Shenoy</name></author><author><name sortKey="Giomarelli, B" uniqKey="Giomarelli B">B. Giomarelli</name></author><author><name sortKey="Thomas, C" uniqKey="Thomas C">C. Thomas</name></author><author><name sortKey="Mcmahon, J B" uniqKey="Mcmahon J">J.B. McMahon</name></author><author><name sortKey="Dauter, Z" uniqKey="Dauter Z">Z. Dauter</name></author><author><name sortKey="O Keefe, B R" uniqKey="O Keefe B">B.R. O'Keefe</name></author><author><name sortKey="Wlodawer, A" uniqKey="Wlodawer A">A. Wlodawer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakabayashi, H" uniqKey="Nakabayashi H">H. Nakabayashi</name></author><author><name sortKey="Taketa, K" uniqKey="Taketa K">K. Taketa</name></author><author><name sortKey="Miyano, K" uniqKey="Miyano K">K. Miyano</name></author><author><name sortKey="Yamane, T" uniqKey="Yamane T">T. Yamane</name></author><author><name sortKey="Sato, J" uniqKey="Sato J">J. Sato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nixon, B" uniqKey="Nixon B">B. Nixon</name></author><author><name sortKey="Stefanidou, M" uniqKey="Stefanidou M">M. Stefanidou</name></author><author><name sortKey="Mesquita, P M M" uniqKey="Mesquita P">P.M.M. Mesquita</name></author><author><name sortKey="Fakioglu, E" uniqKey="Fakioglu E">E. Fakioglu</name></author><author><name sortKey="Segarra, T" uniqKey="Segarra T">T. Segarra</name></author><author><name sortKey="Rohan, L" uniqKey="Rohan L">L. Rohan</name></author><author><name sortKey="Halford, W" uniqKey="Halford W">W. Halford</name></author><author><name sortKey="Palmer, K E" uniqKey="Palmer K">K.E. Palmer</name></author><author><name sortKey="Herold, B C" uniqKey="Herold B">B.C. Herold</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Keefe, B R" uniqKey="O Keefe B">B.R. O'Keefe</name></author><author><name sortKey="Giomarelli, B" uniqKey="Giomarelli B">B. Giomarelli</name></author><author><name sortKey="Barnard, D L" uniqKey="Barnard D">D.L. Barnard</name></author><author><name sortKey="Shenoy, S R" uniqKey="Shenoy S">S.R. Shenoy</name></author><author><name sortKey="Chan, P K S" uniqKey="Chan P">P.K.S. Chan</name></author><author><name sortKey="Mcmahon, J B" uniqKey="Mcmahon J">J.B. McMahon</name></author><author><name sortKey="Palmer, K E" uniqKey="Palmer K">K.E. Palmer</name></author><author><name sortKey="Barnett, B W" uniqKey="Barnett B">B.W. Barnett</name></author><author><name sortKey="Meyerholz, D K" uniqKey="Meyerholz D">D.K. Meyerholz</name></author><author><name sortKey="Wohlford Lenane, C L" uniqKey="Wohlford Lenane C">C.L. Wohlford-Lenane</name></author><author><name sortKey="Mccray, P B" uniqKey="Mccray P">P.B. McCray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Op De Beeck, A" uniqKey="Op De Beeck A">A. Op De Beeck</name></author><author><name sortKey="Voisset, C" uniqKey="Voisset C">C. Voisset</name></author><author><name sortKey="Bartosch, B" uniqKey="Bartosch B">B. Bartosch</name></author><author><name sortKey="Ciczora, Y" uniqKey="Ciczora Y">Y. Ciczora</name></author><author><name sortKey="Cocquerel, L" uniqKey="Cocquerel L">L. Cocquerel</name></author><author><name sortKey="Keck, Z" uniqKey="Keck Z">Z. Keck</name></author><author><name sortKey="Foung, S" uniqKey="Foung S">S. Foung</name></author><author><name sortKey="Cosset, F L" uniqKey="Cosset F">F.-L. Cosset</name></author><author><name sortKey="Dubuisson, J" uniqKey="Dubuisson J">J. Dubuisson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, V S" uniqKey="Raj V">V.S. Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H. Mou</name></author><author><name sortKey="Smits, S L" uniqKey="Smits S">S.L. Smits</name></author><author><name sortKey="Dekkers, D H W" uniqKey="Dekkers D">D.H.W. Dekkers</name></author><author><name sortKey="Muller, M A" uniqKey="Muller M">M.A. Müller</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R. Dijkman</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D. Muth</name></author><author><name sortKey="Demmers, J A A" uniqKey="Demmers J">J.A.A. Demmers</name></author><author><name sortKey="Zaki, A" uniqKey="Zaki A">A. Zaki</name></author><author><name sortKey="Fouchier, R A M" uniqKey="Fouchier R">R.A.M. Fouchier</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V. Thiel</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Rottier, P J M" uniqKey="Rottier P">P.J.M. Rottier</name></author><author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A.D.M.E. Osterhaus</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B.J. Bosch</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L. Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Meer, F J U M" uniqKey="Van Der Meer F">F.J.U.M. van der Meer</name></author><author><name sortKey="De Haan, C A M" uniqKey="De Haan C">C.A.M. de Haan</name></author><author><name sortKey="Schuurman, N M P" uniqKey="Schuurman N">N.M.P. Schuurman</name></author><author><name sortKey="Haijema, B J" uniqKey="Haijema B">B.J. Haijema</name></author><author><name sortKey="Verheije, M H" uniqKey="Verheije M">M.H. Verheije</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B.J. Bosch</name></author><author><name sortKey="Balzarini, J" uniqKey="Balzarini J">J. Balzarini</name></author><author><name sortKey="Egberink, H F" uniqKey="Egberink H">H.F. Egberink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. van Boheemen</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M. Bestebroer</name></author><author><name sortKey="Osterhaus, A D M E" uniqKey="Osterhaus A">A.D.M.E. Osterhaus</name></author><author><name sortKey="Fouchier, R A M" uniqKey="Fouchier R">R.A.M. Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zi Kowska, N E" uniqKey="Zi Kowska N">N.E. Ziółkowska</name></author><author><name sortKey="O Keefe, B R" uniqKey="O Keefe B">B.R. O'Keefe</name></author><author><name sortKey="Mori, T" uniqKey="Mori T">T. Mori</name></author><author><name sortKey="Zhu, C" uniqKey="Zhu C">C. Zhu</name></author><author><name sortKey="Giomarelli, B" uniqKey="Giomarelli B">B. Giomarelli</name></author><author><name sortKey="Vojdani, F" uniqKey="Vojdani F">F. Vojdani</name></author><author><name sortKey="Palmer, K E" uniqKey="Palmer K">K.E. Palmer</name></author><author><name sortKey="Mcmahon, J B" uniqKey="Mcmahon J">J.B. McMahon</name></author><author><name sortKey="Wlodawer, A" uniqKey="Wlodawer A">A. Wlodawer</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>États-Unis</li></country><region><li>Hauts-de-France</li><li>Kentucky</li><li>Nord-Pas-de-Calais</li><li>État de New York</li></region><settlement><li>Ithaca (New York)</li><li>Lille</li></settlement><orgName><li>Université Cornell</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Millet, Jean K" sort="Millet, Jean K" uniqKey="Millet J" first="Jean K." last="Millet">Jean K. Millet</name></region><name sortKey="Labitt, Rachael N" sort="Labitt, Rachael N" uniqKey="Labitt R" first="Rachael N." last="Labitt">Rachael N. Labitt</name><name sortKey="Palmer, Kenneth E" sort="Palmer, Kenneth E" uniqKey="Palmer K" first="Kenneth E." last="Palmer">Kenneth E. Palmer</name><name sortKey="Whittaker, Gary R" sort="Whittaker, Gary R" uniqKey="Whittaker G" first="Gary R." last="Whittaker">Gary R. Whittaker</name></country><country name="France"><region name="Hauts-de-France"><name sortKey="Seron, Karin" sort="Seron, Karin" uniqKey="Seron K" first="Karin" last="Séron">Karin Séron</name></region><name sortKey="Belouzard, Sandrine" sort="Belouzard, Sandrine" uniqKey="Belouzard S" first="Sandrine" last="Belouzard">Sandrine Belouzard</name><name sortKey="Danneels, Adeline" sort="Danneels, Adeline" uniqKey="Danneels A" first="Adeline" last="Danneels">Adeline Danneels</name><name sortKey="Dubuisson, Jean" sort="Dubuisson, Jean" uniqKey="Dubuisson J" first="Jean" last="Dubuisson">Jean Dubuisson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001120 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001120 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:7113895
|texte= Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27424494" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |